Computing Bayes: From Then ‘Til Now

Computing Science Distributed Secure Systems: Then and Now Bibliographical Details Distributed Secure Systems: Then and Now

The early 1980s saw the development of some rather sophisticated distributed systems. These were not merely networked file systems: rather, using remote procedure calls, hierarchical naming, and what would now be called middleware, they allowed a collection of systems to operate as a coherent whole. One such system in particular was developed at Newcastle that allowed pre-existing applications ...

Schizophrenia: Then and Now

EPS—Then and Now

"Slime" played a brief and spectacular role in the 19th century founded by the theory of primordial slime by Ernst Haeckel. However, that substance was never found and eventually abandoned. Further scientific attention slowly began in the 1930s referring to slime as a microbial product and then was inspired by "How bacteria stick" by Costerton et al. in 1978, and the matrix material was conside...

Then and Now

Fluoroquinolones: then and now.

Fluoroquinolones were discovered in the 1960s as a derivative of the antimalarial drug chloroquine. Over the past 40 years, many fluoroquinolones have been developed for use in human and veterinary medicine. As with all classes of antibiotics, resistance to fluoroquinolones is a serious concern, and multiple avenues for resistance are being investigated. Resistance-associated point mutations in...